4 Although many subtypes of NHL exist clinically, most are grouped as either indolent (characterized by a prolonged median survival but generally considered incurable) or aggressive (characterized by rapid growth but with the potential for cure). 3ī-cell lymphomas account for about 85% of all NHL diagnoses. 2 More recent updates of this classification have clarified some less common entities but have left the overall schema intact. The lymphomas were further subdivided into categories based on their clinical behavior (indolent, aggressive, or highly aggressive). The goal was to define disease entities of B cells, T cells, and natural killer (NK) cells that pathologists could recognize and that had clinical relevance. In 1995, the World Health Organization developed a classification that included a combination of morphology, immunotyping, genetic features, and clinical syndromes. NHL encompasses a heterogeneous group of lymphomas that have been classified in various ways.

over the previous 15 years has increased by approximately 4% annually, despite the decline in age-adjusted incidence rates for all cancers combined. In 2009, almost 66,000 cases were anticipated in the U.S. Non-Hodgkin’s lymphoma (NHL) is the most common adult hematological cancer.

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